Evaluation of chemokines CXCL8 and CCL2, serotonin, and vascular endothelial growth factor serum concentrations in healthy dogs from seven breeds with varibale predisposition for canine idiopathic pulmonary fibrosis

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Roels E, Krafft E, Antoine N, Farnir F, Laurila HP, Holopainen S, Rajamäki MM, Clercx C

Res Vet Sci 101 (2015) 57-62, http://dx.doi.org/10.1016/j.rvsc.2015.05.020

The West Highland white terrier (WHWT) is particularly prone to canine idiopathic pulmonary fibrosis (CIPF). We hypothesized that higher circulating concentrations of chemokines CXCL8, CCL2, serotonin (5-HT), or vascular endothelial growth factor (VEGF) could serve as predisposing factors for CIPF development in the WHWT breed. Serum samples from 103 healthy dogs of seven breeds variably predisposed to CIPF were collected. Serum CXCL8 concentrations were higher in healthy WHWT compared with each of the other groups of healthy dogs. Serum CCL2 concentrations were higher in healthy WHWT and Maltese compared with King Charles spaniels and Malinois Belgian shepherds. No relevant inter-breed différences were observed for serum 5-HT concentrations regarding CIPF predisposition. VEGF valued from 89,3% of samples tested were below the kit detection limit. In conclusion, high CXCL8 blood concentrations and possibly CCL2 concentrations might be related to the breed predisposition of the WHWT for CIPF and warrants further investigations.

© 2015 Elsevier Ltd. All rights reserved.

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